Sure, but how can a speck live "well"?
Even if a non-Promethian or non-Faustian stance towards the wilderness were possible, and I'm sure it is, that wouldn't mean I'm wrong to describe the bulk of civilization's history as the story of that stance.
Remember, there's the descriptive and the prescriptive theses. I think we tend to approach nature as raw material to be exploited. That's what civilization is, on my reading, a refuge from nature's inhumanity. We may not consciously understand what we're collectively doing, but that's what things like my philosophical articles are for, to make us see what's hiding in plain sight.
Then there's the question of what the best stance might be. I like to think of this as the problem of imagining what transhumans would do with their extensive knowledge of our alienating position in the universe. The question you're raising is whether happiness as contentment is on the cards for the transhuman. I've argued it's not (links below). We might end up placing higher value on honour and artistic creativity.
