Meanwhile, I'd think any enlightened perspective on our existential condition entails noble suffering. Joy from, or contentment with, the tragedy of that condition would be the brain's way of avoiding the cognitive dissonance in the clash between the nihilism of the cosmic perspective and the parochiality of our limited personal perspectives.

Once you leave behind the personal perspective (egoism), and adopt the cosmos's perspective, as it were, you ought to share the cosmos's indifference and impersonality that run contrary to joy, awe, and contentment. Nature at large feels none of those things. Nature has no values, so it's nihilistic. Its avatars in enlightened sages ought to be the same.