I'm not "dismissing" science because of the necessary simplifications. The simplifications work in that they empower us to modify nature or to exploit its regularities. It's just that there would be no point in understanding something if we had to replicate all its real complexities, in our mind. Therefore, every act of understanding, even in science with all its exact background knowledge, is a simplification, compared to the subject matter's real interrelations with everything else. As soon as we conceive of something, we ignore most of those real interrelations, so the conception or model breaks down the plenum into a manageable part, into a system, process, level, or cycle. That simplification is something we do to empower ourselves at nature's expense. It's what we call "progress."