I suppose this article ends up dealing with a narrower issue, with an obstacle faced by any attempt at an honourable religion such as transhumanism.
A while back I wrote a series on "godless honour" that helps clarify what would be involved. (The first link below links to the others in the series.) I also think pantheism would be the likely basis of an honourable, scientifically informed religion. So the other links below explore that aspect and some others. It's a big question, though, and I don't have a crystal ball.
The benchmark would also take into account a metahistorical perspective, which I've also written on. I compare history to the stages of individual growth, from naive childlike wonder (prehistoric animism) to the teenager's dawning realizations (the Axial age revolutions), to adult stability (oppressive, civilized monarchies), to old age jadedness (modernity and postmodernity or hypermodernity). An honourable late-modern religion would have to avoid the respective drawbacks of these historical stages, such as theistic delusions.
Again, though, I'm only gesturing towards an answer to this big question.
