I don't see how that strategy would work against nihilism. The question would be about the most fitting personal or civilizational response to the best model of natural facts. Sure, unmodeled nature wouldn't feel horror in response to itself. Nihilism is about the clash between science and folk psychology and intuitions, roughly speaking. So the nihilist says that when we adopt an inkling of the cosmic perspective, with philosophical naturalism, we naturally lose faith in the intuitions that support our self-confidence, patriotism, loves, curiosities, etc. Or at least, we ought to suffer some alienation in grasping the cosmic irrelevance of our mundane concerns.

I don't see how that kind of nihilism is incoherent. I see it rather as a challenge for our species to become transhuman, to be fit to live at a cosmic scale.