I can see how entheogens could help fulfill part of the transhuman agenda. As the four-part documentary on Netflix says, entheogens are how we (radically) change our mind. I've written about that as "enlightenment," but I've also equated enlightenment with the likely transhuman mentality.

But then there's the problem of changing our bodies. The mystical perspective engendered by shamanism and entheogens is supposed to allow us to settle for the limitations of our mortality. We're united with the cosmos already, so why bother trying to perfect the human body? Isn't that just egoitistical? Transhumanists are more progressive, though, and perhaps also more "satanic" than that. They say we shouldn't be content with what nature's given us. We should be able to do everything for ourselves, which would make us gods (divine creators of worlds and of ourselves).

Science-fiction explores various transhumanist scenarios, both the optimistic and the pessimsitic ones. It's hard to know how the technologies would change our social systems, including capitalism. The reason entheogens are prohibited is because of their tendency to radicalize the user, as happened in the US in the 1960s.